Crystal structure of human osteoclast cathepsin K complex with E-64

被引：115

作者：

Zhao, BG

Janson, CA

Amegadzie, BY

DAlessio, K

Griffin, C

Hanning, CR

Jones, C

Kurdyla, J

McQueney, M

Qiu, XY

Smith, WW

AbdelMeguid, SS

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT MACROMOL SCI,KING OF PRUSSIA,PA 19406

[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT PROT BIOCHEM,KING OF PRUSSIA,PA 19406

[3] SMITHKLINE BEECHAM PHARMACEUT,DEPT GENE EXPRESS SCI,KING OF PRUSSIA,PA 19406

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 02期

关键词：

D O I：

10.1038/nsb0297-109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of human cathepsin K, a potential target for treatment of osteoporosis. reveals active site differences with homologous cysteine proteinases that should enable the design of cathepsin K selective inhibitors.

引用

页码：109 / 111

页数：3

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