Elevation of serum interleukin-6 but not serum-soluble interleukin-2 receptor in children with Crohn's disease

被引:27
作者
Bross, DA
Leichtner, AM
Zurakowski, D
Law, T
Bousvaros, A
机构
[1] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DIV GASTROENTEROL,COMBINED PROGRAM GASTROENTEROL,BOSTON,MA 02115
[2] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT RES COMP & BIOSTAT,BOSTON,MA 02115
[3] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT LAB MED,BOSTON,MA 02115
关键词
Crohn's disease; inflammatory bowel disease; interleukin; interleukin-2R;
D O I
10.1097/00005176-199608000-00012
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Previous studies have demonstrated elevated serum levels of interleukin-6 (IL-6) and the soluble interleukin-2 receptor (IL-2R, CD25) in individuals with inflammatory bowel disease (IBD). The aim of our study was to compare serum IL-6 and IL-2R levels to see if one marker better distinguished IBD from other intestinal disorders or better reflected disease activity. Blood samples were obtained from 41 pediatric patients with Crohn's disease, 22 with ulcerative colitis, 19 with other gastrointestinal inflammatory disorders, and 13 with functional abdominal pain. Disease activity and disease location were determined for patients with Crohn's disease and ulcerative colitis. Serum levels of IL-6 and IL-2R were determined by using an enzyme-linked immunosorbent assay. Mean serum levels of IL-6 were significantly elevated (p < 0.05) in patients with Crohn's disease when compared with individuals with ulcerative colitis, other gastrointestinal inflammatory disorders, or functional abdominal pain. By comparison, there was no significant difference in mean serum levels of IL-2R in individuals with Crohn's disease compared with these other groups. Patients with moderate/severe Crohn's disease had elevated mean serum levels of IL-6 and IL-2R when compared with those with mild and inactive disease (p < 0.05); however, neither marker distinguished between inactive and mild disease. IL-6 correlated better with the erythrocyte sedimentation rate (ESR; r = 0.57, p < 0.001) than did IL-2R (r = 0.28, p < 0.01). Our results suggest that elevated IL-6 levels are more likely to be seen in patients with Crohn's disease. Although IL-6 may be a better marker for Crohn's disease and active disease than IL-2R, it does not appear to offer any advantage over the ESR.
引用
收藏
页码:164 / 171
页数:8
相关论文
共 33 条
[1]  
ARMITAGE P, 1987, STATISTICAL METHODS, P107
[2]   PLASMA INTERLEUKIN-2 AND A SOLUBLE SHED INTERLEUKIN-2 RECEPTOR IN SERUM OF PATIENTS WITH CROHNS-DISEASE - EFFECT OF CYCLOSPORINE [J].
BRYNSKOV, J ;
TVEDE, N .
GUT, 1990, 31 (07) :795-799
[3]   DIFFERENTIAL EXPRESSION OF CD25 (INTERLEUKIN-2 RECEPTOR) ON LAMINA PROPRIA T-CELLS AND MACROPHAGES IN THE INTESTINAL LESIONS IN CROHNS-DISEASE AND ULCERATIVE-COLITIS [J].
CHOY, MY ;
WALKERSMITH, JA ;
WILLIAMS, CB ;
MACDONALD, TT .
GUT, 1990, 31 (12) :1365-1370
[4]   SOLUBLE INTERLEUKIN-2 RECEPTOR IN CROHNS-DISEASE - RELATION OF SERUM CONCENTRATIONS TO DISEASE-ACTIVITY [J].
CRABTREE, JE ;
JUBY, LD ;
HEATLEY, RV ;
LOBO, AJ ;
BULLIMORE, DW ;
AXON, ATR .
GUT, 1990, 31 (09) :1033-1036
[5]   CORRELATION OF SERUM INTERLEUKIN-6 LEVELS WITH JOINT INVOLVEMENT AND THROMBOCYTOSIS IN SYSTEMIC JUVENILE RHEUMATOID-ARTHRITIS [J].
DEBENEDETTI, F ;
MASSA, M ;
ROBBIONI, P ;
RAVELLI, A ;
BURGIO, GR ;
MARTINI, A .
ARTHRITIS AND RHEUMATISM, 1991, 34 (09) :1158-1163
[6]   SPONTANEOUS RELEASE OF INTERFERON-GAMMA BY INTESTINAL LAMINA PROPRIA LYMPHOCYTES IN CROHNS-DISEASE - KINETICS OF INVITRO RESPONSE TO INTERFERON-GAMMA INDUCERS [J].
FAIS, S ;
CAPOBIANCHI, MR ;
PALLONE, F ;
DIMARCO, P ;
BOIRIVANT, M ;
DIANZANI, F ;
TORSOLI, A .
GUT, 1991, 32 (04) :403-407
[7]   EVIDENCE FOR CONTINUOUS STIMULATION OF INTERLEUKIN-6 PRODUCTION IN CROHNS-DISEASE [J].
GROSS, V ;
ANDUS, T ;
CAESAR, I ;
ROTH, M ;
SCHOLMERICH, J .
GASTROENTEROLOGY, 1992, 102 (02) :514-519
[8]  
Hochberg Y., 1987, Multiple comparison procedures
[9]  
HOSMER DW, 1989, APPL LOGISTIC REGRES, P6
[10]   RELATIONSHIP OF FUNCTIONAL AND ANTIGENIC INTERLEUKIN-6 TO DISEASE-ACTIVITY IN INFLAMMATORY BOWEL-DISEASE [J].
HYAMS, JS ;
FITZGERALD, JE ;
TREEM, WR ;
WYZGA, N ;
KREUTZER, DL .
GASTROENTEROLOGY, 1993, 104 (05) :1285-1292