Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

被引：109

作者：

Soshnikova, N

Zechner, D

Huelsken, J

Mishina, Y

Behringer, RR

Taketo, MM

Crenshaw, EB

Birchmeier, W

机构：

[1] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

[2] Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA

[3] Kyoto Univ, Grad Sch Med, Dept Pharmacol, Sakyo Ku, Kyoto 6068501, Japan

[4] Childrens Hosp Philadelphia, Ctr Childhood Commun, Mammalian Neurogenet Grp, Philadelphia, PA 19104 USA

来源：

GENES & DEVELOPMENT | 2003年 / 17卷 / 16期

关键词：

limb ventral ectoderm; proximal-distal axis; FGF; engrailed-1; frizzled;

D O I：

10.1101/gad.263003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

By conditional gene ablation in mice, we found that beta-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that beta-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling.

引用

页码：1963 / 1968

页数：6

共 33 条

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Ahn K, 2001, DEVELOPMENT, V128, P4449

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