Tumour-dendritic hybrid cell vaccination for the treatment of patients with malignant melanoma: immunological effects and clinical results

被引：61

作者：

Trefzer, U ^{[1
]}

Herberth, G ^{[1
]}

Wohlan, K ^{[1
]}

Milling, A ^{[1
]}

Thiemann, M ^{[1
]}

Sharav, T ^{[1
]}

Sparbier, K ^{[1
]}

Sterry, W ^{[1
]}

Walden, P ^{[1
]}

机构：

[1] Humboldt Univ, Univ Med Berlin, Dept Dermatol & Allergy, Charite, D-10117 Berlin, Germany

来源：

VACCINE | 2005年 / 23卷 / 17-18期

关键词：

tumour vaccine; melanoma; T cell; immune monitoring; immune escape; clinical trial;

D O I：

10.1016/j.vaccine.2005.01.081

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hybrid cell vaccines of autologous tumour cells fused with allogenic dendritic cells (DC) combine the tumour's antigenicity with the immune-stimulatory capacity of mature dendritic cells and allogenic MHC class II molecules to activate T cell help and induce tumour-specific cytotoxic T cells. This concept was tested in a clinical trial with melanoma stage III and IV patients. Seventeen patients were evaluated: one experienced complete, one partial response and six stable disease with long survival times. Eleven of fourteen patients, clinical responders and non-responders alike, mounted high-frequency T cell responses to various tumour-associated antigens. Failing clinical responses correlated with loss of antigenicity. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2367 / 2373

页数：7

共 41 条

[1] Antitumor effect of immunizations with fusions of dendritic and glioma cells in a mouse brain tumor model [J].

Akasaki, Y ;

Kikuchi, T ;

Homma, S ;

Abe, T ;

Kofe, D ;

Ohno, T .

JOURNAL OF IMMUNOTHERAPY, 2001, 24 (02) :106-113

[2] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[3] Tumor-specific CD4+ T lymphocytes from cancer patients are required for optimal induction of cytotoxic T cells against the autologous tumor [J].

Baxevanis, CN ;

Voutsas, IF ;

Tsitsilonis, OE ;

Gritzapis, AD ;

Sotiriadou, R ;

Papamichail, M .

JOURNAL OF IMMUNOLOGY, 2000, 164 (07) :3902-3912

[4] Help for cytotoxic-T-cell responses is mediated by CD40 signalling [J].

Bennett, SRM ;

Carbone, FR ;

Karamalis, F ;

Flavell, RA ;

Miller, JFAP ;

Heath, WR .

NATURE, 1998, 393 (6684) :478-480

[5]

Boczkowski D, 2000, CANCER RES, V60, P1028

[6] EFFICACY OF SYNTHETIC VACCINES IN THE INDUCTION OF CYTOTOXIC T-LYMPHOCYTES - COMPARISON OF THE COSTIMULATING SUPPORT PROVIDED BY HELPER T-CELLS AND LIPOAMINO ACID [J].

BORGES, E ;

WIESMULLER, KH ;

JUNG, G ;

WALDEN, P .

JOURNAL OF IMMUNOLOGICAL METHODS, 1994, 173 (02) :253-263

[7]

BUCALA R, 2002, CANC IMMUNE THERAPY, P119

[8] COSTIMULATION OF ANTITUMOR IMMUNITY BY THE B7 COUNTERRECEPTOR FOR THE LYMPHOCYTE-T MOLECULES CD28 AND CTLA-4 [J].

CHEN, LP ;

ASHE, S ;

BRADY, WA ;

HELLSTROM, I ;

HELLSTROM, KE ;

LEDBETTER, JA ;

MCGOWAN, P ;

LINSLEY, PS .

CELL, 1992, 71 (07) :1093-1102

[9]

el-Shamil K, 1999, EUR J IMMUNOL, V29, P3295, DOI 10.1002/(SICI)1521-4141(199910)29:10<3295::AID-IMMU3295>3.3.CO

[10]

2-E

← 1 2 3 4 5 →