Functional interaction between various glutamate receptors

被引:2
作者
Boldyrev, AA
机构
[1] Moscow MV Lomonosov State Univ, Ctr Mol Med, Moscow, Russia
[2] Moscow MV Lomonosov State Univ, Int Biotechnol Ctr, Dept Biochem, Moscow, Russia
[3] Russian Acad Med Sci, Inst Neurol, Moscow, Russia
关键词
glutamate; ionotropic and metabotropic receptors; Na+/K+-ATPase; oxidative stress;
D O I
10.1007/BF02682242
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The interaction of glutamate with various receptors in glutamatergic neurons and functional interaction between glutamate receptors are reviewed. It is hypothesized that metabotropic receptors perform defensive functions in the brain by protecting neurons from neurotoxic effects caused by excessive glutamate release.
引用
收藏
页码:823 / 829
页数:7
相关论文
共 35 条
  • [1] MODULATION OF N-METHYL-D-ASPARTATE RECEPTORS BY HYDROXYL RADICALS IN RAT CORTICAL-NEURONS IN-VITRO
    AIZENMAN, E
    [J]. NEUROSCIENCE LETTERS, 1995, 189 (01) : 57 - 59
  • [2] Alabovskii V V, 1999, Biull Eksp Biol Med, V127, P290
  • [3] AMBROSINI A, 1995, MOL PHARMACOL, V47, P1057
  • [4] Possible involvement of nitric oxide in NMDA-induced glutamate release in the rat striatum: An in vivo microdialysis study
    Bogdanov, MB
    Wurtman, RJ
    [J]. NEUROSCIENCE LETTERS, 1997, 221 (2-3) : 197 - 201
  • [5] Mechanism of oxidative damage of dog kidney Na/K-ATPase
    Boldyrev, A
    Kurella, E
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 222 (02) : 483 - 487
  • [6] Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species
    Boldyrev, A
    Song, R
    Lawrence, D
    Carpenter, DO
    [J]. NEUROSCIENCE, 1999, 94 (02) : 571 - 577
  • [7] Boldyrev A A, 1995, Biokhimiia, V60, P1536
  • [8] Effect of nitroso compounds on Na/K-ATPase
    Boldyrev, AA
    Bulygina, ER
    Kramarenko, GG
    Vanin, AF
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1997, 1321 (03): : 243 - 251
  • [9] Sources of reactive oxygen species production in excitotoxin-stimulated cerebellar granule cells
    Boldyrev, AA
    Carpenter, DO
    Huentelman, MJ
    Peters, CM
    Johnson, P
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 256 (02) : 320 - 324
  • [10] Is Na,K-ATPase the target of oxidative stress?
    Boldyrev, AA
    Bulygina, ER
    Kramarenko, GG
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1996, 121 (03) : 253 - 256