Interrogation by toxin

被引:10
作者
Palmiter, R [1 ]
机构
[1] Howard Hughes Med Inst, Los Angeles, CA USA
[2] Univ Washington, Seattle, WA 98195 USA
关键词
D O I
10.1038/90770
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A variation on an approach that uses diphtheria toxin to ablate specific cells in mice provides a better means of assessing biological function.
引用
收藏
页码:731 / 732
页数:2
相关论文
共 10 条
  • [1] DWARF MICE PRODUCED BY GENETIC ABLATION OF GROWTH HORMONE-EXPRESSING CELLS
    BEHRINGER, RR
    MATHEWS, LS
    PALMITER, RD
    BRINSTER, RL
    [J]. GENES & DEVELOPMENT, 1988, 2 (04) : 453 - 461
  • [2] TARGETING OF AN INDUCIBLE TOXIC PHENOTYPE IN ANIMAL-CELLS
    BORRELLI, E
    HEYMAN, R
    HSI, M
    EVANS, RM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (20) : 7572 - 7576
  • [3] INFERTILITY IN MALE TRANSGENIC MICE - DISRUPTION OF SPERM DEVELOPMENT BY HSV-TK EXPRESSION IN POSTMEIOTIC GERM-CELLS
    BRAUN, RE
    LO, D
    PINKERT, CA
    WIDERA, G
    FLAVELL, RA
    PALMITER, RD
    BRINSTER, RL
    [J]. BIOLOGY OF REPRODUCTION, 1990, 43 (04) : 684 - 693
  • [4] Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
    Hara, J
    Beuckmann, CT
    Nambu, T
    Willie, JT
    Chemelli, RM
    Sinton, CM
    Sugiyama, F
    Yagami, K
    Goto, K
    Yanagisawa, M
    Sakurai, T
    [J]. NEURON, 2001, 30 (02) : 345 - 354
  • [5] Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor
    Louie, GV
    Yang, W
    Bowman, ME
    Choe, S
    [J]. MOLECULAR CELL, 1997, 1 (01) : 67 - 78
  • [6] EXPRESSION CLONING OF A DIPHTHERIA-TOXIN RECEPTOR - IDENTITY WITH A HEPARIN-BINDING EGF-LIKE GROWTH-FACTOR PRECURSOR
    NAGLICH, JG
    METHERALL, JE
    RUSSELL, DW
    EIDELS, L
    [J]. CELL, 1992, 69 (06) : 1051 - 1061
  • [7] CELL LINEAGE ABLATION IN TRANSGENIC MICE BY CELL-SPECIFIC EXPRESSION OF A TOXIN GENE
    PALMITER, RD
    BEHRINGER, RR
    QUAIFE, CJ
    MAXWELL, F
    MAXWELL, IH
    BRINSTER, RL
    [J]. CELL, 1987, 50 (03) : 435 - 443
  • [8] An essential role for ectodomain shedding in mammalian development
    Peschon, JJ
    Slack, JL
    Reddy, P
    Stocking, KL
    Sunnarborg, SW
    Lee, DC
    Russell, WE
    Castner, BJ
    Johnson, RS
    Fitzner, JN
    Boyce, RW
    Nelson, N
    Kozlosky, CJ
    Wolfson, MF
    Rauch, CT
    Cerretti, DP
    Paxton, RJ
    March, CJ
    Black, RA
    [J]. SCIENCE, 1998, 282 (5392) : 1281 - 1284
  • [9] REPLACEMENT OF DISEASED MOUSE-LIVER BY HEPATIC CELL TRANSPLANTATION
    RHIM, JA
    SANDGREN, EP
    DEGEN, JL
    PALMITER, RD
    BRINSTER, RL
    [J]. SCIENCE, 1994, 263 (5150) : 1149 - 1152
  • [10] Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice
    Saito, M
    Iwawaki, T
    Taya, C
    Yonekawa, H
    Noda, M
    Inui, Y
    Mekada, E
    Kimata, Y
    Tsuru, A
    Kohno, K
    [J]. NATURE BIOTECHNOLOGY, 2001, 19 (08) : 746 - 750