The parvovirus capsid odyssey: from the cell sur face to the nucleus

被引：51

作者：

Harbison, Carole E. ^{[1
]}

Chiorini, John A. ^{[2
]}

Parrish, Colin R. ^{[1
]}

机构：

[1] Cornell Univ, Coll Vet Med, Baker Inst Anim Hlth, Dept Microbiol & Immunol, Ithaca, NY 14853 USA

[2] Natl Inst Dent & Craniofacial Res, AAV Biol Sect, Gene Therapy & Therapeut Branch, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

TRENDS IN MICROBIOLOGY | 2008年 / 16卷 / 05期

关键词：

D O I：

10.1016/j.tim.2008.01.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During cellular entry and infection, the parvovirus capsid follows a complex path from the cell surface to the nucleus, where the DNA is replicated. Various receptors have been characterized that bind to different parvoviruses and mediate their entry into cells. However, the subsequent trafficking pathways within the endosomal system, cytoplasm and into the nucleus are still not well defined. Studies of viruses entering various cell types under different conditions show particles located in many different endosomal compartments, within the cytoplasm and in the nucleus with significant variations in timing and distribution. Here, we define the previously unresolved issues that are now better understood for the infection pathways of these viruses, and outline some of the areas that remain to be clarified in future studies.

引用

页码：208 / 214

页数：7

共 61 条

[1] A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8 [J].