D-ribose in glycation and protein aggregation

被引：121

作者：

Wei, Yan ^{[1
]}

Han, Chan Shuai ^{[1
,3
]}

Zhou, Jun ^{[1
,3
]}

Liu, Ying ^{[1
]}

Chen, Lan ^{[1
]}

He, Rong Qiao ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China

[3] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2012年 / 1820卷 / 04期

基金：

北京市自然科学基金;

关键词：

D-ribose; Glycation; Protein aggregation; Advanced glycation end product; Cognitive impairment; AMYOTROPHIC-LATERAL-SCLEROSIS; PANCREATIC BETA-CELLS; END-PRODUCTS; OXIDATIVE STRESS; NONENZYMATIC GLYCOSYLATION; MAILLARD REACTION; HIGH CYTOTOXICITY; ALPHA-SYNUCLEIN; SERUM; GLUCOSE;

D O I：

10.1016/j.bbagen.2012.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Background: D-ribose is a naturally occurring pentose monosaccharide present in all living cells and their microenvironments and is a key component of numerous biomolecules involved in many important metabolic pathways. It also participates in the glycation of proteins producing advanced glycation end products (AGEs) that lead to cell dysfunction and death. As recent studies show, ribosylation, a rapid process, causes protein aggregation in vitro and in vivo. Scope of review: This review summarizes the relationship between ribosylation, protein aggregation, cell death and cognitive impairments. Major conclusion: D-ribose is active in glycation and induces protein aggregation, rapidly producing AGEs in vitro and in vivo. General significance: Ribosylation, leading to the production of significant amounts of AGEs both extracellularly and intracellularly, may be involved in cell dysfunction and subsequent cognitive impairments. This review may be a useful reference for studies on the pharmacokinetics of D-ribose action. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：488 / 494

页数：7

共 77 条

[1]

D-RIBOSE AND DEOXY-D-RIBOSE INDUCE APOPTOSIS IN HUMAN QUIESCENT PERIPHERAL-BLOOD MONONUCLEAR-CELLS [J].