Cochliobolic acid, a novel metabolite produced by Cochliobolus lunatus, inhibits binding of TGF-alpha to the EGF receptor in a SPA assay

被引：4

作者：

Robinson, N ^{[1
]}

Gibson, TM ^{[1
]}

ChicarelliRobinson, MI ^{[1
]}

Cameron, L ^{[1
]}

Hylands, PJ ^{[1
]}

Wilkinson, D ^{[1
]}

机构：

[1] UNIV BRISTOL,SCH CHEM,BRISTOL BS8 1TS,AVON,ENGLAND

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 01期

关键词：

D O I：

10.1021/np9605293

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cochliobolic acid (1), a novel biologically active natural product, is produced by submerged fermentation of Cochliobolus lunatus. Compound 1 was determined to be a novel polyketide possessing a substituted tetrahydrofuran ring, a conjugated polyene chain and a 1,2-diketone moiety, by interpretation of NMR, MS, and UV/vis spectroscopic data. Compound 1 inhibits the binding of TGF-alpha to the EGF receptor of the human epidermal cell line A431 in a SPA assay with an IC50 of 1.6 mu M.

引用

页码：6 / 8

页数：3

共 24 条

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