Cloning and sequence analysis of Hsp89αΔN, a new member of the Hsp90 gene family

被引：15

作者：

Schweinfest, CW

Graber, MW

Henderson, KW

Papas, TS

Baron, PL

Watson, DK

机构：

[1] Med Univ S Carolina, Hollings Canc Ctr, Ctr Mol & Struct Biol, Charleston, SC 29425 USA

[2] Med Univ S Carolina, Dept Surg, Charleston, SC 29425 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1398卷 / 01期

关键词：

heat shock; gene duplication; pancreas;

D O I：

10.1016/S0167-4781(98)00031-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified a novel member of the Hsp90 gene family. This new gene, Hsp89 alpha Delta N, is remarkable in that it appears to represent a recent evolutionary event. Hsp89 alpha Delta N is identical in nucleotide sequence to Hsp89 alpha for codons 224 to 732 (end). However, Hsp89 alpha Delta N cDNA lacks the ATP/geldanamycin binding domain (codons 1-220), instead containing 544 nucleotides of unique DNA at its 5' end including 30 novel codons. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：18 / 24

页数：7

共 11 条

[1] A ROLE FOR HSP90 IN CELL-CYCLE CONTROL - WEE1 TYROSINE KINASE-ACTIVITY REQUIRES INTERACTION WITH HSP90 [J].