Synthesis of acetoxy stabilised indolequinones as precursors to model eumelanin polymers

被引：6

作者：

Atkinson, S ^{[1
]}

Meredith, P ^{[1
]}

机构：

[1] Univ Queensland, Ctr Biophoton & Laser Sci, Dept Phys, Brisbane, Qld 4072, Australia

来源：

SYNLETT | 2003年 / 12期

关键词：

5,6-dihydroxyindole; 5,6-diacetoxyindole; melanin biopolymers; melanin precursors; nitration of activated aromatic compound;

D O I：

10.1055/s-2003-41409

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report an efficient synthetic route to obtaining a stable analogue of 5,6-dihydroxyindole. These analogues can be used to build controlled composition model melanin biopolymers for solid state and spectroscopic studies of this important biomolecule.

引用

页码：1853 / 1855

页数：3

共 8 条

[1]

BENIGNI JD, 1965, J HETEROCYCLIC CHEM, V21, P1183

[2]

ITO S, 1986, BIOCHIM BIOPHYS ACTA, V883, P115

[3]

MASON HS, 1953, PIGMENT CELL GROWTH

[4] A NEW PIGMENT FROM STREPTOMYCES-LAVENDULAE [J].

MIKAMI, Y ;

TAKAHASHI, K ;

FUKUSHIMA, K ;

YAZAWA, K ;

ARAI, T ;

KUBO, A ;

SAITO, N ;

KAWAKAMI, N .

JOURNAL OF ANTIBIOTICS, 1987, 40 (03) :385-387

[5] EFFICIENT SYNTHESIS OF 5,6-DIACETOXYINDOLE - A STABLE EUMELANIN PRECURSOR [J].

MURPHY, BP .

JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (26) :5873-5875

[6]

Nicolaus R. A., 1968, MELANINS

[7]

Novellino L, 1999, SYNTHESIS-STUTTGART, P793

[8] SYNTHESIS AND CHARACTERIZATION OF MELANINS FROM DIHYDROXYINDOLE-2-CARBOXYLIC ACID AND DIHYDROXYINDOLE [J].

ORLOW, SJ ;

OSBER, MP ;

PAWELEK, JM .

PIGMENT CELL RESEARCH, 1992, 5 (03) :113-121

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