Spatial and temporal specification of neural fates by transcription factor codes

被引：227

作者：

Guillemot, Francois ^{[1
]}

机构：

[1] Natl Inst Med Res, London NW7 1AA, England

来源：

DEVELOPMENT | 2007年 / 134卷 / 21期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

DEVELOPING SPINAL-CORD; CORTICAL PROGENITOR CELLS; PRONEURAL GENES; BHLH GENES; OLIGODENDROCYTE DIFFERENTIATION; HOMEODOMAIN PROTEIN; SUBTYPE IDENTITY; NEURONAL FATE; VERTEBRATE NEUROGENESIS; NERVOUS-SYSTEM;

D O I：

10.1242/dev.006379

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The vertebrate central nervous system contains a great diversity of neurons and glial cells, which are generated in the embryonic neural tube at specific times and positions. Several classes of transcription factors have been shown to control various steps in the differentiation of progenitor cells in the neural tube and to determine the identity of the cells produced. Recent evidence indicates that combinations of transcription factors of the homeodomain and basic helix- loop- helix families establish molecular codes that determine both where and when the different kinds of neurons and glial cells are generated.

引用

页码：3771 / 3780

页数：10

共 85 条

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