Acute effect of atorvastatin on coronary circulation measured by transthoracic Doppler echocardiography in patients without coronary artery disease by angiography

被引:48
作者
Hinoi, T [1 ]
Matsuo, S [1 ]
Tadehara, F [1 ]
Tsujiyama, S [1 ]
Yamakido, M [1 ]
机构
[1] Kure Kyosai Hosp, Dept Internal Med, Hiroshima, Japan
关键词
D O I
10.1016/j.amjcard.2005.02.050
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thirty-two patients were randomly assigned to treatment with placebo or atorvastatin. The time-averaged peak diastolic velocity (APDV) of the left anterior descending artery without stenosis was measured by transthoracic Doppler echocardiography at rest and under hyperemic conditions before and 1 hour after treatment. APDV increased significantly in the atorvastatin group, at rest and under hyperemic conditions, and coronary flow velocity reserve also increased in the atorvastatin group compared with patients given placebo. Atorvastatin improved the blood flow velocity of the normal coronary artery < 1 hour after administration in patients without coronary artery disease by angiography. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:89 / 91
页数:3
相关论文
共 13 条
[1]   LIPID-LOWERING AND PLAQUE REGRESSION - NEW INSIGHTS INTO PREVENTION OF PLAQUE DISRUPTION AND CLINICAL EVENTS IN CORONARY-DISEASE [J].
BROWN, BG ;
ZHAO, XQ ;
SACCO, DE ;
ALBERS, JJ .
CIRCULATION, 1993, 87 (06) :1781-1791
[2]   REGRESSION OF CORONARY-ARTERY DISEASE AS A RESULT OF INTENSIVE LIPID-LOWERING THERAPY IN MEN WITH HIGH-LEVELS OF APOLIPOPROTEIN-B [J].
BROWN, G ;
ALBERS, JJ ;
FISHER, LD ;
SCHAEFER, SM ;
LIN, JT ;
KAPLAN, C ;
ZHAO, XQ ;
BISSON, BD ;
FITZPATRICK, VF ;
DODGE, HT .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (19) :1289-1298
[3]   REDUCTION IN SERUM-CHOLESTEROL WITH PRAVASTATIN IMPROVES ENDOTHELIUM-DEPENDENT CORONARY VASOMOTION IN PATIENTS WITH HYPERCHOLESTEROLEMIA [J].
EGASHIRA, K ;
HIROOKA, Y ;
KAI, H ;
SUGIMACHI, M ;
SUZUKI, S ;
INOU, T ;
TAKESHITA, A .
CIRCULATION, 1994, 89 (06) :2519-2524
[4]   SHORT-TERM CHOLESTEROL-LOWERING DECREASES SIZE AND SEVERITY OF PERFUSION ABNORMALITIES BY POSITRON EMISSION TOMOGRAPHY AFTER DIPYRIDAMOLE IN PATIENTS WITH CORONARY-ARTERY DISEASE - A POTENTIAL NONINVASIVE MARKER OF HEALING CORONARY ENDOTHELIUM [J].
GOULD, KL ;
MARTUCCI, JP ;
GOLDBERG, DI ;
HESS, MJ ;
EDENS, RP ;
LATIFI, R ;
DUDRICK, SJ .
CIRCULATION, 1994, 89 (04) :1530-1538
[5]   Noninvasive assessment of significant left anterior descending coronary artery stenosis by coronary flow velocity reserve with transthoracic color Doppler echocardiography [J].
Hozumi, T ;
Yoshida, K ;
Ogata, Y ;
Akasaka, T ;
Asami, Y ;
Takagi, T ;
Morioka, S .
CIRCULATION, 1998, 97 (16) :1557-1562
[6]   The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. [J].
Kureishi, Y ;
Luo, ZY ;
Shiojima, I ;
Bialik, A ;
Fulton, D ;
Lefer, DJ ;
Sessa, WC ;
Walsh, K .
NATURE MEDICINE, 2000, 6 (09) :1004-1010
[7]   Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors [J].
Laufs, U ;
La Fata, V ;
Plutzky, J ;
Liao, JK .
CIRCULATION, 1998, 97 (12) :1129-1135
[8]   Lovastatin enhances Ecto-5′-nucleotidase activity and cell surface expression in endothelial cells implication of Rho-family GTPases [J].
Ledoux, S ;
Laouari, D ;
Essig, M ;
Runembert, I ;
Trugnan, G ;
Michel, JB ;
Friedlander, G .
CIRCULATION RESEARCH, 2002, 90 (04) :420-427
[9]  
OMISH D, 1990, LANCET, V336, P129
[10]   Prospective serial evaluation of myocardial perfusion and lipids during the first six months of pravastatin therapy - Coronary artery disease regression single photon emission computed tomography monitoring trial [J].
Schwartz, RG ;
Pearson, TA ;
Kalaria, VG ;
Mackin, ML ;
Williford, DJ ;
Awasthi, A ;
Shah, A ;
Rains, A ;
Guido, JJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 42 (04) :600-610