Amygdala hyperreactivity in borderline personality disorder: Implications for emotional dysregulation

被引:443
作者
Donegan, NH
Sanislow, CA
Blumberg, HP
Fulbright, RK
Lacadie, C
Skudlarski, P
Gore, JC
Olson, IR
McGlashan, TH
Wexler, BE
机构
[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA
基金
美国国家卫生研究院;
关键词
amygdala; borderline personality disorder; functional magnetic resonance imaging; emotional dysregulation; hypervigilance; Ekman faces;
D O I
10.1016/S0006-3223(03)00636-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Disturbed interpersonal relations and emotional dysregulation are fundamental aspects of borderline personality disorder (BPD). The amygdala plays important roles in modulating vigilance and generating negative emotional states and is often abnormally reactive in disorders of mood and emotion. The aim of this study was to assess amygdala reactivity in BPD patients relative to normal control subjects. We hypothesized that amygdala hyperreactivity contributes to hypervigilance, emotional dysregulation, and disturbed interpersonal relations in BPD. Methods: Using functional magnetic resonance imaging, we examined neural responses to 20-sec blocks of neutral, happy, sad, and fearful facial expression (or a fixation point) in 15 BPD and 15 normal control subjects. The DSM IV-diagnosed BPD patients and the normal control subjects were assessed by a clinical research team in a medical school psychiatry department. Results: Borderline patients showed significantly greater left amygdala activation to the facial expressions of emotion (vs. a fixation point) compared with normal control subjects. Post-scan debriefing revealed that some borderline patients had difficulty disambiguating neutral faces or found them threatening. Conclusions: Pictures of human emotional expressions elicit robust differences in amygdala activation levels in borderline patients, compared with normal control subjects, and can be used as probes to study the neuropathophysiologic basis of borderline personality disorder.
引用
收藏
页码:1284 / 1293
页数:10
相关论文
共 51 条
[1]   The human amygdala in social judgment [J].
Adolphs, R ;
Tranel, D ;
Damasio, AR .
NATURE, 1998, 393 (6684) :470-474
[2]   The primate amygdala and the neurobiology of social behavior: Implications for understanding social anxiety [J].
Amaral, DG .
BIOLOGICAL PSYCHIATRY, 2002, 51 (01) :11-17
[3]   Lesions of the human amygdala impair enhanced perception of emotionally salient events [J].
Anderson, AK ;
Phelps, EA .
NATURE, 2001, 411 (6835) :305-309
[4]   DOUBLE DISSOCIATION OF CONDITIONING AND DECLARATIVE KNOWLEDGE RELATIVE TO THE AMYGDALA AND HIPPOCAMPUS IN HUMANS [J].
BECHARA, A ;
TRANEL, D ;
DAMASIO, H ;
ADOLPHS, R ;
ROCKLAND, C ;
DAMASIO, AR .
SCIENCE, 1995, 269 (5227) :1115-1118
[5]  
Benjamin L. S., 1993, INTERPERSONAL DIAGNO
[6]   Response and habituation of the human amygdala during visual processing of facial expression [J].
Breiter, HC ;
Etcoff, NL ;
Whalen, PJ ;
Kennedy, WA ;
Rauch, SL ;
Buckner, RL ;
Strauss, MM ;
Hyman, SE ;
Rosen, BR .
NEURON, 1996, 17 (05) :875-887
[7]   RELATIONSHIP OF HIPPOCAMPUS AND AMYGDALA TO CORONAL MRI LANDMARKS [J].
BRONEN, RA ;
CHEUNG, G .
MAGNETIC RESONANCE IMAGING, 1991, 9 (03) :449-457
[8]   FACTOR STRUCTURE OF BORDERLINE PERSONALITY-DISORDER CRITERIA [J].
CLARKIN, JF ;
HULL, JW ;
HURT, SW .
JOURNAL OF PERSONALITY DISORDERS, 1993, 7 (02) :137-143
[9]   PSYSCOPE - AN INTERACTIVE GRAPHIC SYSTEM FOR DESIGNING AND CONTROLLING EXPERIMENTS IN THE PSYCHOLOGY LABORATORY USING MACINTOSH COMPUTERS [J].
COHEN, J ;
MACWHINNEY, B ;
FLATT, M ;
PROVOST, J .
BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS, 1993, 25 (02) :257-271
[10]  
Davis M., 2000, The Amygdala, V2, P213, DOI 10.1146/annurev.ne.15.030192.002033