G1 cyclins block the Ime1 pathway to make mitosis and meiosis incompatible in budding yeast

被引:79
作者
Colomina, N [1 ]
Garí, E [1 ]
Gallego, C [1 ]
Herrero, E [1 ]
Aldea, M [1 ]
机构
[1] Univ Lleida, Dept Ciencies Med Bas, Lleida 25198, Catalunya, Spain
关键词
cell cycle; G(1) cyclins; Ime; 1; meiosis; nutrients;
D O I
10.1093/emboj/18.2.320
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Diploid yeast cells switch from mitosis to meiosis when starved of essential nutrients, While G(1) cyclins play a key role in initiating the mitotic cell cycle, entry into meiosis depends on Ime1, a transcriptional activator regulated by both nutritional and cell-type signals. We show here that G(1) cyclins downregulate IME1 transcription and prevent the accumulation of the Ime1 protein within the nucleus, which results in repression of early-meiotic gene expression, as G(1)-cyclin deficient cells do not require nutrient starvation to undergo meiosis, G(1) cyclin would exert its role by transmitting essential nutritional signals to Ime1 function. The existence of a negative cross-talk mechanism between mitosis and meiosis may help explain why these two developmental options are incompatible in budding yeast.
引用
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页码:320 / 329
页数:10
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