Synthesis of aryl ketones by the Pd-catalyzed C-H activation of arenes and intermolecular carbopalladation of nitriles

被引：231

作者：

Zhou, CX ^{[1
]}

Larock, RC ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 08期

关键词：

D O I：

10.1021/ja038687l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The palladium-catalyzed reaction of simple arenes and nitriles provides good to excellent yields of aryl ketones or the corresponding hindered imines. The addition of a small amount of DMSO increases the yields dramatically. Both intermolecular and intramolecular examples of this process are successful. This novel chemistry is believed to involve palladium-catalyzed C?H activation, followed by carbopalladation of the nitrile. Copyright © 2004 American Chemical Society.

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页码：2302 / 2303

页数：2

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