Assessment of Feeding Behavior in Laboratory Mice

被引:194
作者
Ellacott, Kate L. J. [1 ,2 ]
Morton, Gregory J. [3 ,4 ]
Woods, Stephen C. [5 ,6 ,7 ]
Tso, Patrick [5 ,6 ,7 ]
Schwartz, Michael W. [3 ,4 ]
机构
[1] Vanderbilt Univ, Med Ctr, Mouse Metab Phenotyping Ctr, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Med Ctr, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA
[3] Univ Washington, Mouse Metab Phenotyping Ctr, Seattle, WA 98109 USA
[4] Diabet & Obes Ctr Excellence, Dept Med, Seattle, WA 98109 USA
[5] Univ Cincinnati, Mouse Metab Phenotyping Ctr, Cincinnati, OH 45267 USA
[6] Univ Cincinnati, Dept Psychiat, Cincinnati, OH 45267 USA
[7] Univ Cincinnati, Dept Pathol & Lab Med, Cincinnati, OH 45267 USA
关键词
BODY-WEIGHT; SPEED CONGENICS; ENERGY-BALANCE; FOOD-INTAKE; MOUSE; C57BL/6J; OBESITY; LEPTIN; CHOLECYSTOKININ; DEFICIENT;
D O I
10.1016/j.cmet.2010.06.001
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
The global obesity epidemic has heightened the need for an improved understanding of how body weight is controlled, and research using mouse models is critical to this effort. In this perspective, we provide a conceptual framework for investigation of feeding behavior in this species, with an emphasis on factors that influence study design, data interpretation, and relevance to feeding behavior in humans. Although we focus on the mouse, the principles presented can be applied to most other animal models. This document represents the current consensus view of investigators from the National Institutes of Health (NIH)-funded Mouse Metabolic Phenotyping Centers (MMPCs).
引用
收藏
页码:10 / 17
页数:8
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