Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea

被引：79

作者：

Rojas, A ^{[1
]}

Bah, M ^{[1
]}

Rojas, JI ^{[1
]}

Gutiérrez, DM ^{[1
]}

机构：

[1] Univ Autonoma Queretaro, Fac Quim, Dept Invest Quim & Farmacol Prod Nat, Cerro de las Campanas 76010, Queretaro, Mexico

来源：

PLANTA MEDICA | 2000年 / 66卷 / 08期

关键词：

D O I：

10.1055/s-2000-9774

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Bioassay directed fractionation of the (1:1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of isolated guinea pig ileum. Contractions induced by histamine, acetylcholine, BaCl2 and KCI on the ileum were also significantly blocked by this monoterpene glucoside, which suggests that this compound might be interfering with calcium influx into the smooth muscle cells.

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收藏

页码：765 / 767

页数：3

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