Food restriction selectively increases hypothalamic orexin-B levels in lactating rats

被引:28
作者
Cai, XJ
Denis, R
Vernon, RG
Clapham, JC
Wilson, S
Arch, JRS
Williams, G
机构
[1] Univ Liverpool, Dept Med, Diabet & Endocrinol Res Grp, Liverpool L69 3GA, Merseyside, England
[2] Hannah Res Inst, Ayr KA6 5HL, Scotland
[3] SmithKline Beecham Pharmaceut, Harlow CM19 5AD, Essex, England
基金
英国医学研究理事会;
关键词
orexin/hypocretin; lactation; food restriction; energy homeostasis;
D O I
10.1016/S0167-0115(00)00209-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Orexins are hypothalamic peptides implicated in the regulation of ingestive and other behaviours. Here we investigated prepro-orexin expression and hypothalamic orexin-A and -B levels in lactating rats, which display marked hyperphagia, with or without food restriction for 2 days or treatment with bromocriptine, which inhibits milk production and thus reduces the energy losses of lactation. Neither prepro-orexin gene expression nor hypothalamic orexin-A peptide levels were changed in any of these lactating groups compared with age-matched virgin controls. However, hypothalamic orexin-B levels were significantly higher in lactating rats that were food-restricted for 2 days (P < 0.05) compared with non-lactating controls and with lactating rats that were either freely-fed or bromocriptine-treated. Thus, food restriction superimposed on lactation selectively increases hypothalamic orexin-B levels, suggesting that orexin-A and -B may be differentially released or cleared. Changes in orexin-B availability may influence physiological activities other than energy homeostasis, perhaps inducing arousal. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:163 / 168
页数:6
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