TAM receptors and the clearance of apoptotic cells

被引：181

作者：

Lemke, Greg ^{[1
]}

Burstyn-Cohen, Tal ^{[2
]}

机构：

[1] Salk Inst Biol Studies, MNL L, La Jolla, CA 92037 USA

[2] Hadassah Med Ctr, Jerusalem, Israel

来源：

CLEARANCE OF DYING CELLS IN HEALTHY AND DISEASED IMMUNE SYSTEMS | 2010年 / 1209卷

关键词：

Gas6; Protein S; TAM receptors; tyrosine kinase; apoptosis; TYRO-3 FAMILY RECEPTORS; TYROSINE KINASE; PROTEIN-S; ALPHA-V-BETA-5; INTEGRIN; MEDIATED PHAGOCYTOSIS; STRUCTURAL BASIS; MER; GAS6; PHOSPHATIDYLSERINE; GENE;

D O I：

10.1111/j.1749-6632.2010.05744.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Tyro3, Axl, and Mer (TAM) receptor tyrosine kinases and their ligands Gas6 and Protein S are required for the optimal phagocytosis of apoptotic cells in the mature immune, nervous, and reproductive systems. Genetic analyses in mice, rats, and humans reveal that this receptor-ligand system plays an especially important role in the phagocytosis that is triggered by the "eat-me" signal phosphatidylserine. Deficiencies in TAM signaling lead to human retinal dystrophies and may contribute to lupus and other human autoimmune diseases. The TAM system appears to interact and cooperate with several other phagocytic networks, including scavenger receptor and integrin-based systems, and may serve as a signaling hub that integrates these systems.

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收藏

页码：23 / 29

页数：7

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