Histone Variants in Metazoan Development

被引：120

作者：

Banaszynski, Laura A. ^{[1
]}

Allis, C. David ^{[1
]}

Lewis, Peter W. ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Chromatin Biol & Epigenet, New York, NY 10065 USA

来源：

DEVELOPMENTAL CELL | 2010年 / 19卷 / 05期

关键词：

INACTIVE X-CHROMOSOME; PRIMORDIAL GERM-CELLS; CORE HISTONE; CONSTITUTIVE HETEROCHROMATIN; PERICENTRIC HETEROCHROMATIN; DROSOPHILA-MELANOGASTER; DIFFERENTIAL EXPRESSION; EPIGENETIC MECHANISMS; POLYMERASE-II; SNF2; FAMILY;

D O I：

10.1016/j.devcel.2010.10.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Embryonic development is regulated by both genetic and epigenetic mechanisms, with nearly all DNA-templated processes influenced by chromatin architecture Sequence variations in histone proteins, core components of chromatin, provide a means to generate diversity in the chromatin structure, resulting in distinct and profound biological outcomes in the developing embryo Emerging literature suggests that epigenetic contributions from histone variants play key roles in a number of developmental processes such as the initiation and maintenance of pericentric heterochromatin, X-inactivation, and germ cell differentiation Here, we review the role of histone variants in the embryo with particular emphasis on early mammalian development

引用

页码：662 / 674

页数：13

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