DRESS syndrome, a drug reaction which remains bad known from pediatricians

被引：9

作者：

Autret-Leca, E. ^{[1
]}

Norbert, K. ^{[2
]}

Bensouda-Grimaldi, L. ^{[1
]}

Jonville-Bera, A. -P. ^{[1
]}

Saliba, E. ^{[2
]}

Bentata, J. ^{[3
]}

Barthez-Carpentier, M. -A. ^{[4
]}

机构：

[1] CHRU Tours, Hop Bretonneau, Ctr Reg Pharmacovigilance & Informat Medicament, Serv Pharmacol, F-37044 Tours 09, France

[2] CHRU Tours, Hop Gatien de Clocheville, Serv Reanimat Pediat & Neonatol, F-37044 Tours 09, France

[3] CHR Orleans, Hop Porte Madeleine, Serv Peidat Gen, F-45000 Orleans, France

[4] CHRU Tours, Hop Gatien de Clocheville, Serv Neurochirurg & Neurol, F-37044 Tours 09, France

来源：

ARCHIVES DE PEDIATRIE | 2007年 / 14卷 / 12期

关键词：

D O I：

10.1016/j.arcped.2007.07.016

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The DRESS syndrome (Rash with Eosinophilia and Systemic Symptoms) is a drug hypersensitivity reaction poorly known by paediatricians. It occurs within 1 to 8 weeks of treatment. Clinical features associate in variable patterns, fever, rash, lymphadenopathies, arthritis and potentially life-threatening damage (hepatitis, nephritis, pneumonitis), hyperleucocytosis and eosinophilia. This condition must be early recognized in order to immediately stop suspect drugs. A 6.5 year old girl had a febrile rash, hyperleucocytosis, lymph nodes and cytolitic hepatitis probably due to phenobarbital. Diagnosis of DRESS syndrome was performed only 13 days after the beginning of the eruption. Evolution was favorable but characterized by the recurrence of the febrile eruption with pleuritis. DRESS syndrome is a well described disease that occurs during treatment with a number drugs, particularly anti-epileptic drugs. Steroid therapy and immunoglobulins are proposed for treatment but have not been evaluated. (c) 2007 Elsevier Masson SAS. Tous droits reserves.

引用

页码：1439 / 1441

页数：3

共 19 条

[1] Anticonvulsant hypersensitivity syndrome associated with reactivation of cytomegalovirus [J].