Multifunctional nanoparticle platforms for in vivo MRI enhancement and photodynamic therapy of a rat brain cancer

被引：135

作者：

Kopelman, R

Koo, YEL

Philbert, M

Moffat, BA

Reddy, GR

McConville, P

Hall, DE

Chenevert, TL

Bhojani, MS

Buck, SM

Rehemtulla, A

Ross, BD

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

[3] Mol Therapeut Inc, Ann Arbor, MI 48104 USA

[4] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2005年 / 293卷 / 01期

关键词：

MRI contrast agent; molecular imaging; nanoparticles; cancer; polyacrylamide (PAA); polyethylene glycol (PEG); photodynamic therapy (PDT);

D O I：

10.1016/j.jmmm.2005.02.061

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A paradigm for brain cancer detection, treatment, and monitoring is established. Multifunctional biomedical nanoparticles (30-60nm) containing photosensitizer externally deliver reactive oxygen species (ROS) to cancer cells while simultaneously enhancing magnetic resonance imaging (MRI) contrast providing real-time tumor kill measurement. Plasma residence time control and specific cell targeting are achieved. A 5min treatment in rats halted and even reversed in vivo tumor growth after 3-4 days post-treatment. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：404 / 410

页数：7

共 12 条

[1] REQUIREMENT OF VASCULAR INTEGRIN ALPHA(V)BETA(3) FOR ANGIOGENESIS [J].