(Hydroxymethyl)acylfulvene: An illudin derivative with superior antitumor properties

被引：96

作者：

McMorris, TC

Kelner, MJ

Wang, W

Yu, J

Estes, LA

Taetle, R

机构：

[1] UNIV CALIF SAN DIEGO,DEPT PATHOL,LA JOLLA,CA 92093

[2] UNIV ARIZONA,ARIZONA CANC CTR,DIV HEMATOL,TUCSON,AZ 85724

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 09期

关键词：

D O I：

10.1021/np960450y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Reaction of the fungal sesquiterpene illudin S with excess paraformaldehyde in dilute H2SO4 gives (hydroxymethyl)acylfulvene. The primary allylic hydroxyl thus formed can undergo very facile replacement by a variety of nucleophiles. (Hydroxymethyl)acylfulvene (MGI.114) was more toxic than a precursor, acylfulvene, but less toxic than the parent compound illudin S to HL 60 cells.

引用

页码：896 / 899

页数：4

共 16 条

[1]

AMMIRATI TF, 1985, POISONOUS MUSHROOMS, P290

[2]

BECK WT, 1993, CANC MED, V1, P782

[3]

KELNER MJ, 1995, ANTICANCER RES, V15, P867

[4] CHARACTERIZATION OF ILLUDIN-S SENSITIVITY IN DNA REPAIR-DEFICIENT CHINESE-HAMSTER CELLS - UNUSUALLY HIGH-SENSITIVITY OF ERCC2 AND ERCC3 DNA HELICASE-DEFICIENT MUTANTS IN COMPARISON TO OTHER CHEMOTHERAPEUTIC-AGENTS [J].