Quantitative evaluation of rRNA in Alzheimer's disease

被引：35

作者：

da Silva, AMA

Payao, SLM

Borsatto, B

Bertolucci, PHF

Smith, MDC

机构：

[1] UNIFESP, Escola Paulista Med, Dept Morfol, Disciplina Genet, BR-04023900 Sao Paulo, Brazil

[2] Fac Med Marilia, Hemoctr FAMEMA, Sao Paulo, Brazil

[3] UNIFESP, Escola Paulista Med, Dept Clin Neurol, BR-04023900 Sao Paulo, Brazil

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2000年 / 120卷 / 1-3期

基金：

巴西圣保罗研究基金会;

关键词：

aging; Alzheimer's disease; rRNA;

D O I：

10.1016/S0047-6374(00)00180-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ribosomal RNA (rRNA) genes are located in nucleolus during active transcription and are transcribed by RNA polymerase I. This group of genes is involved in transcription and translation processes which can modulate gene expression. The association between rRNA levels and aging has been reported. In the present study, Eve investigated the ratio of mature rRNA 28S and 18S in peripheral blood of 15 Alzheimer's disease (AD) patients, 15 elderly healthy controls and 15 healthy young controls. Our results showed a statistically significant decrease of the mature rRNA 28S/18S ratio in AD patients when compared with the elderly and young control groups. Thus we can suggest that there is a possible change in the transcriptional or maturation process or a preferential degradation of the 28S subunit in AD. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：57 / 64

页数：8

共 37 条

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