Role of activated nuclear factor-κB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck

Background. Nuclear factor-kappa B (NF-kappa B), a transcription factor known to modulate expression of factors involved in inflammation, immunity, proliferation, and apoptosis, is constitutively activated and plays a role in pathogenesis and therapeutic resistance in head and neck squamous cell carcinoma (HNSCC). Understanding the molecular alterations leading to aberrant NF-kappa B activation in HNSCC may direct investigators to novel therapeutic targets. Methods. Results of laboratory and clinical studies are reviewed. Results. The structure, function, and activation of NF-kappa B, products of NF-kappa B target genes and their role in HNSCC oncogenesis, and current NF-kappa B modulating interventions are described. Conclusions. Aberrant NF-kappa B activation contributes to the expression of oncogenes and the malignant phenotype observed in HNSCC. NF-kappa B, along with providing a link between cancer and inflammation, may serve as an appropriate therapeutic target to inhibit tumor growth and sensitize cancer cells to established cytotoxic anticancer therapies. (c) 2007 Wiley Periodicals, Inc.