Melt Processing of Chitosan-Based Fibers and Fiber-Mesh Scaffolds for the Engineering of Connective Tissues

被引：17

作者：

Correlo, Vitor M. ^{[1
,2
]}

Costa-Pinto, Ana R. ^{[1
,2
]}

Sol, Paula ^{[1
,2
]}

Covas, Jose A. ^{[3
,4
]}

Bhattacharya, Mrinal ^{[5
]}

Neves, Nuno M. ^{[1
,2
]}

Reis, Rui L. ^{[1
,2
]}

机构：

[1] Univ Minho, Res Grp Biomat Biodegradables & Biomimet 3Bs, European Inst Excellence Tissue Engn & Regenerat, P-4806909 Taipas, Guimaraes, Portugal

[2] PT Govt Associated Lab, IBB Inst Biotechnol & Bioengn, Braga, Portugal

[3] Univ Minho, IPC, Dept Polymer Engn, P-4800058 Guimaraes, Portugal

[4] Univ Minho, Inst Nanostruct Nanomodelling & Nanofabricat I3N, Dept Polymer Engn, P-4800058 Guimaraes, Portugal

[5] Univ Minnesota, Minneapolis, MN 55455 USA

来源：

MACROMOLECULAR BIOSCIENCE | 2010年 / 10卷 / 12期

关键词：

chitosan; fiber mesh; osteoblasts; scaffolds; tissue engineering; KNITTED SILK SCAFFOLD; OSTEOGENIC DIFFERENTIATION; PORE-SIZE; MECHANICAL-PROPERTIES; FLOW PERFUSION; IN-VITRO; CELLS; PROLIFERATION; ADHESION; POROSITY;

D O I：

10.1002/mabi.201000011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We report the production of chitosan-based fibers and chitosan fiber-mesh structures by melt processing (solvent-free) to be used as tissue-engineering scaffolds. The melt-based approach used to produce the scaffolds does not change their main characteristics, including the surface roughness and microporosity. The porosity, pore size, interconnectivity and mechanical performance of the scaffolds are all within the range required for various tissue-engineering applications. Biological assessments are performed in direct-contact assays. Cells are able to colonize the scaffold, including the inner porous structure. The cells show high indices of viability in all of the scaffold types.

引用

页码：1495 / 1504

页数：10

共 43 条

[1]

Chitosan/polyester-based scaffolds for cartilage tissue engineering: Assessment of extracellular matrix formation [J].