Novel 4,4-bis(trifluoromethyl) imidazolines as stereospecific and orally active Acyl CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents

被引：8

作者：

Boswell, GA ^{[1
]}

Li, HY ^{[1
]}

Delucca, I ^{[1
]}

Billheimer, JT ^{[1
]}

Drummond, S ^{[1
]}

Gillies, PJ ^{[1
]}

Robinson, C ^{[1
]}

机构：

[1] DUPONT MERCK PHARMACEUT CO,DIV CHEM SCI,EXPTL STN,WILMINGTON,DE 19880

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 07期

关键词：

D O I：

10.1016/0960-894X(96)00137-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new class of very potent, systemically-active ACAT inhibitors based on a 4,4-bis(trifluoromethyl)imidazoline ring has been discovered. Compound 6 and its R-enantiomer 6a exhibited very potent oral activities in lowering the serum cholesterol in the animals. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：885 / 888

页数：4

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