Translational complexity of the fragile x mental retardation protein: Insights from the fly

被引:12
作者
Broadie, K [1 ]
Pan, LY [1 ]
机构
[1] Vanderbilt Univ, Dept Sci Biol, Kennedy Ctr Res Human Dev, Nashville, TN 37232 USA
关键词
D O I
10.1016/j.molcel.2005.03.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Through the awesome power of Drosophila genetics, two recent studies (Costa et al., 2005; Zarnescu et al., 2005) reveal novel mechanisms by which the Fragile X Mental Retardation protein regulates selective mRNA translation, controlling key steps of germline development during oogenesis and neuronal development during synaptogenesis.
引用
收藏
页码:757 / 759
页数:3
相关论文
共 10 条
[1]   Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-cependent protein kinase II [J].
Atkins, CM ;
Nozaki, N ;
Shigeri, Y ;
Soderling, TR .
JOURNAL OF NEUROSCIENCE, 2004, 24 (22) :5193-5201
[2]   Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation [J].
Barnard, DC ;
Ryan, K ;
Manley, JL ;
Richter, JD .
CELL, 2004, 119 (05) :641-651
[3]   Phosphorylation-induced autoinhibition regulates the cytoskeletal protein lethal (2) giant larvae [J].
Betschinger, J ;
Eisenhaber, F ;
Knoblich, JA .
CURRENT BIOLOGY, 2005, 15 (03) :276-282
[4]   Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target [J].
Brittis, PA ;
Lu, Q ;
Flanagan, JG .
CELL, 2002, 110 (02) :223-235
[5]   The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway [J].
Costa, A ;
Wang, Y ;
Dockendorff, TC ;
Erdjument-Bromage, H ;
Tempst, P ;
Schedl, P ;
Jongens, TA .
DEVELOPMENTAL CELL, 2005, 8 (03) :331-342
[6]   New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants [J].
Ruiz-Canada, C ;
Ashley, J ;
Moeckel-Cole, S ;
Drier, E ;
Yin, J ;
Budnik, V .
NEURON, 2004, 42 (04) :567-580
[7]   A role for the cytoplasmic polyadenylation element in NMDA receptor-regulated mRNA translation in neurons [J].
Wells, DG ;
Dong, X ;
Quinlan, EM ;
Huang, YS ;
Bear, MF ;
Richter, JD ;
Fallon, JR .
JOURNAL OF NEUROSCIENCE, 2001, 21 (24) :9541-9548
[8]   The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at Synapses [J].
Zalfa, F ;
Giorgi, M ;
Primerano, B ;
Moro, A ;
Di Penta, A ;
Reis, S ;
Oostra, B ;
Bagni, C .
CELL, 2003, 112 (03) :317-327
[9]   Fragile X protein functions with Lgl and the PAR complex in flies and mice [J].
Zarnescu, DC ;
Jin, P ;
Betschinger, J ;
Nakamoto, M ;
Wang, Y ;
Dockendorff, TC ;
Feng, Y ;
Jongens, TA ;
Sisson, JC ;
Knoblich, JA ;
Warren, ST ;
Moses, K .
DEVELOPMENTAL CELL, 2005, 8 (01) :43-52
[10]   Fathoming fragile X in fruit flies [J].
Zhang, YQ ;
Broadie, K .
TRENDS IN GENETICS, 2005, 21 (01) :37-45