Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia

被引：80

作者：

Bertho, JM

Demarquay, C

Frick, J

Joubert, C

Arenales, S

Jacquet, N

Sorokine-Durm, I

Chau, Q

Lopez, M

Aigueperse, J

Gorin, NC

Gourmelon, P

机构：

[1] Inst Protect & Surete Nucl, Dept Protect Sante Homme & Dosimetrie, Sect Autonome Radiobiol Appl Med, F-92265 Fontenay Aux Roses, France

[2] Inst Protect & Surete Nucl, Lab Dosimetrie Biol Multiparametr, F-92265 Fontenay Aux Roses, France

[3] Inst Protect & Surete Nucl, Serv Dosimetrie, F-92265 Fontenay Aux Roses, France

[4] CHU St Antoine, Lab Therapie Cellulaire & Radioprotect Accidentel, Paris, France

[5] Hop St Antoine, Serv Malad Sang, F-75571 Paris, France

[6] CHU St Antoine, INSERM, U76, Paris, France

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2001年 / 77卷 / 06期

关键词：

D O I：

10.1080/09553000110043711

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Purpose: To follow plasma Flt3-ligand (FL) concentrations in irradiated animals in order to evaluate it as an indicator of bone marrow damage for the management of accidental radiation-induced aplasia. Materials and methods: Non-human primates were irradiated at doses ranging from 2 to 8 Gy, using whole- or partial-body irradiation. Plasma FL concentrations and blood cell counts were determined daily. Results: FL concentrations increased as early as day 2 after irradiation, whatever the irradiation dose. Increase in plasma FL concentration on day 5 post-irradiation was correlated with radiation dose and with the severity of radiation-induced aplasia. During the course of aplasia, FL concentrations in plasma were inversely correlated with neutrophil counts. A peak in FL concentration appeared before the neutrophil nadir, and the subsequent decrease in FL concentration was correlated with the recovery of blood-cell populations. Conclusions : Monitoring plasma FL concentration can be used as an indicator of radiation-induced marrow aplasia, and this may be of use in accidental irradiation situations.

引用

页码：703 / 712

页数：10

共 43 条

[1]

[Anonymous], 2017, Sources, Effects and Risks of Ionizing Radiation. United Nations Scientific Committee on the Effects of Atomic Radiation. UNSCEAR 2016 Report to the General Assembly, with Scientific Annexes

[2] BONE-MARROW TRANSPLANTATION AFTER THE CHERNOBYL NUCLEAR ACCIDENT [J].

BARANOV, A ;

GALE, RP ;

GUSKOVA, A ;

PIATKIN, E ;

SELIDOVKIN, G ;

MURAVYOVA, L ;

CHAMPLIN, RE ;

DANILOVA, N ;

YEVSEEVA, L ;

PETROSYAN, L ;

PUSHKAREVA, S ;

KONCHALOVSKY, M ;

GORDEEVA, A ;

PROTASOVA, T ;

REISNER, Y ;

MICKEY, MR ;

TERASAKI, PI .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (04) :205-212

[3]

BARANOV AE, 1994, BLOOD, V83, P596

[4]

Bertho JM, 2000, SCAND J IMMUNOL, V52, P53

[5]

Blumenthal RD, 2000, CANCER, V88, P333, DOI 10.1002/(SICI)1097-0142(20000115)88:2<333::AID-CNCR13>3.0.CO

[6]

2-D

[7]

BOND VP, 1953, RADIAT RES, V6, P554

[8]

BURGER H, 1990, BLOOD, V76, P2229

[9]

BUTTURINI A, 1988, LANCET, V2, P471

[10] Mechanism of flt3 ligand expression in bone marrow failure: Translocation from intracellular stores to the surface of T lymphocytes after chemotherapy-induced suppression of hematopoiesis [J].

Chklovskaia, E ;

Jansen, W ;

Nissen, C ;

Lyman, SD ;

Rahner, C ;

Landmann, L ;

Wodnar-Filipowicz, A .

BLOOD, 1999, 93 (08) :2595-2604

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