Synthesis of penta-N-protected homocaldopentamine and its selective acylation

被引：21

作者：

Pak, JK ^{[1
]}

Hesse, M ^{[1
]}

机构：

[1] Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 23期

关键词：

D O I：

10.1021/jo980689e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the penta-N-protected polyamine homocaldopentamine {PA 4333, 1, tert-butyl N-[9-allyl-16-azido-13-(2,2,2-trichloro-tert-butoxycarbonyl)-5-(trimethylsilylethylsulfonyl)-5,9,13-triazahexadec-1-yl]carbamate}, containing five independent amino-protecting groups is described. These five protecting groups used-allyl, azido, tert-butoxycarbonyl (BOC), 2,2,2-trichloro-tert-butoxycarbonyl (TCBOC), and trimethylsilylethylsulfonyl (SES)-were removed selectively. The acylation with p-methoxycinnamoyl chloride at each nitrogen of the pentaamine was determined.

引用

页码：8200 / 8204

页数：5

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