Influence of maternal and fetal glucokinase mutations in gestational diabetes

被引：82

作者：

Spyer, G

Hattersley, AT

Sykes, JE

Sturley, RH

MacLeod, KM

机构：

[1] Postgrad Med Sch, Dept Diabet & Vasc Med, Exeter, Devon, England

[2] Royal Devon & Exeter Hosp, Dept Obstet & Gynecol, Exeter EX2 5DW, Devon, England

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2001年 / 185卷 / 01期

关键词：

glucokinase mutation; gestational diabetes; fetal birth weight;

D O I：

10.1067/mob.2001.113127

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We report 2 insulin-treated pregnancies in a mother with hyperglycemia resulting from a glucokinase gene mutation. The inheritance of a glucokinase mutation in 1 child reduced his intrauterine growth (birth weight less than first percentile) by reducing fetal insulin secretion, We discuss the implications for obstetric management of patients with glucokinase mutations.

引用

页码：240 / 241

页数：2

共 3 条

[1] USE OF FETAL ULTRASOUND TO SELECT METABOLIC THERAPY FOR PREGNANCIES COMPLICATED BY MILD GESTATIONAL DIABETES [J].