The physiology of the lymphatic system

被引：552

作者：

Swartz, MA

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[2] Northwestern Univ, Dept Chem Engn, Evanston, IL 60208 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2001年 / 50卷 / 1-2期

关键词：

lymphatic physiology; lymphatic uptake; lymphangiogenesis; edema; lymphatic metastasis; review;

D O I：

10.1016/S0169-409X(01)00150-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper presents an overview of the anatomy, physiology, and biology of the lymphatic system specifically relevant to lymphatic drug delivery. We will briefly review the classic fluid and solute transport literature, and also examine the current research in lymphatic endothelial cell biology and tumor metastasis in the lymphatics because of the increasing potential for targeted delivery of immunomodulators, chemotherapeutics, and genetic material to specific lymph nodes (Refs. [1-7]). (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：3 / 20

页数：18

共 193 条

[1] Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) [J].