Association between IL28B polymorphisms and first-phase viral load decrease in chronic hepatitis C virus-infected patients treated with peginterferon alfa-2b/ribavirin

被引：7

作者：

Arends, Joop E. ^{[1
,2
]}

Fransen, Justin H. ^{[1
,2
]}

Hoepelman, Andy I. M. ^{[1
]}

van Baarle, Debbie ^{[1
,2
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Internal Med & Infect Dis, NL-3508 GA Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Immunol, NL-3508 GA Utrecht, Netherlands

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2011年 / 38卷 / 06期

关键词：

IL28B; Hepatitis C; Single nucleotide polymorphism; GENETIC-VARIATION; INTERFERON-ALPHA; RIBAVIRIN; THERAPY;

D O I：

10.1016/j.ijantimicag.2011.08.010

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Host polymorphisms in the IL28B region have recently been associated with outcome of treatment for hepatitis C virus (HCV) infection. This study clearly shows an association between first-phase viral load decrease and the IL28B rs12979860 polymorphism in chronic HCV-infected patients. Furthermore, a higher treatment efficiency factor (epsilon) was found in those HCV-infected patients with a CC genotype compared with those with a CT and TT genotype. This study highlights the importance of host response mechanisms in relation to favourable clearance of HCV. (C) 2011 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：538 / 539

页数：2

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