Coccidioidomycosis in solid organ transplantation

被引:145
作者
Blair, JE
Logan, JL
机构
[1] Mayo Clin Scottsdale, Div Infect Dis, Scottsdale, AZ 85259 USA
[2] Univ Arizona, Coll Med, Dept Internal Med, Tucson, AZ USA
关键词
D O I
10.1086/323463
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Coccidioidomycosis is an endemic fungal infection of the southwestern United States. Normally a self-limited infection in healthy hosts, coccidioidomycosis can become a serious complication in patients who have had solid organ transplantation. Among patients whose solid organ transplantation was complicated by coccidioidomycosis, the infection has a variety of clinical presentations. Disseminated disease is common and has substantial morbidity. Patients at risk for coccidioidal infection should be identified so that antifungal prophylactic therapy can be initiated. Treatment options include amphotericin B or azoles. Secondary prophylaxis is recommended because relapse is frequent.
引用
收藏
页码:1536 / 1544
页数:9
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