Packaging of Fat: An Evolving Model of Lipid Droplet Assembly and Expansion

被引：200

作者：

Brasaemle, Dawn L. ^{[1
,2
]}

Wolins, Nathan E. ^{[3
]}

机构：

[1] Rutgers State Univ, Rutgers Ctr Lipid Res, New Brunswick, NJ 08901 USA

[2] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA

[3] Washington Univ, Sch Med, Dept Med, Div Geriatr & Nutr Sci, St Louis, MO 63110 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ADIPOSE TRIGLYCERIDE LIPASE; CHANARIN-DORFMAN-SYNDROME; HORMONE-SENSITIVE LIPASE; ENDOPLASMIC-RETICULUM; ACYL-COA; DIACYLGLYCEROL ACYLTRANSFERASE-2; TRIACYLGLYCEROL SYNTHESIS; DEFICIENT MICE; PERILIPIN-A; RAT-LIVER;

D O I：

10.1074/jbc.R111.309088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Lipid droplets (LDs) are organelles found in most types of cells in the tissues of vertebrates, invertebrates, and plants, as well as in bacteria and yeast. They differ from other organelles in binding a unique complement of proteins and lacking an aqueous core but share aspects of protein trafficking with secretory membrane compartments. In this minireview, we focus on recent evidence supporting an endoplasmic reticulum origin for LD formation and discuss recent findings regarding LD maturation and fusion.

引用

页码：2273 / 2279

页数：7

共 73 条

[1]

Role of the proline knot motif in oleosin endoplasmic reticulum topology and oil body targeting [J].

Abell, BM ;

Holbrook, LA ;

Abenes, M ;

Murphy, DJ ;

Hills, MJ ;

Moloney, MM .

PLANT CELL, 1997, 9 (08) :1481-1493

[2]

The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets [J].

Adeyo, Oludotun ;

Horn, Patrick J. ;

Lee, SungKyung ;

Binns, Derk D. ;

Chandrahas, Anita ;

Chapman, Kent D. ;

Goodman, Joel M. .

JOURNAL OF CELL BIOLOGY, 2011, 192 (06) :1043-1055

[3]

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic [J].

Bartz, Rene ;

Li, Wen-Hong ;

Venables, Barney ;

Zehmer, John K. ;

Roth, Mary R. ;

Welti, Ruth ;

Anderson, Richard G. W. ;

Liu, Pingsheng ;

Chapman, Kent D. .

JOURNAL OF LIPID RESEARCH, 2007, 48 (04) :837-847

[4]

COPI Complex Is a Regulator of Lipid Homeostasis [J].

Beller, Mathias ;

Sztalryd, Carole ;

Southall, Noel ;

Bell, Ming ;

Jaeckle, Herbert ;

Auld, Douglas S. ;

Oliver, Brian .

PLOS BIOLOGY, 2008, 6 (11) :2530-2549

[5]

Seipin Is a Discrete Homooligomer [J].

Binns, Derk ;

Lee, SungKyung ;

Hilton, Christopher L. ;

Jiang, Qiu-Xing ;

Goodman, Joel M. .

BIOCHEMISTRY, 2010, 49 (50) :10747-10755

[6]

BLANCHETTEMACKIE EJ, 1995, J LIPID RES, V36, P1211

[7]

SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity [J].

Bostrom, Pontus ;

Andersson, Linda ;

Rutberg, Mikael ;

Perman, Jeanna ;

Lidberg, Ulf ;

Johansson, Bengt R. ;

Fernandez-Rodriguez, Julia ;

Ericson, Johanna ;

Nilsson, Tommy ;

Boren, Jan ;

Olofsson, Sven-Olof .

NATURE CELL BIOLOGY, 2007, 9 (11) :1286-U139

[8]

The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis [J].

Brasaemle, Dawn L. .

JOURNAL OF LIPID RESEARCH, 2007, 48 (12) :2547-2559

[9]

Perilipin A and the control of triacylglycerol metabolism [J].

Brasaemle, Dawn L. ;

Subramanian, Vidya ;

Garcia, Anne ;

Marcinkiewicz, Amy ;

Rothenberg, Alexis .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2009, 326 (1-2) :15-21

[10]

Phosphatidic Acid Phosphatase, a Key Enzyme in the Regulation of Lipid Synthesis [J].

Carman, George M. ;

Han, Gil-Soo .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (05) :2593-2597

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