Absence of Chlamydia pneumoniae and signs of atherosclerotic cardiovascular disease in adolescents with systemic lupus erythematosus

被引:7
作者
Bowser, Corinna S. [1 ]
Kumar, Swati [2 ]
Salciccioli, Louis [3 ]
Kutlin, Andrei [2 ]
Lazar, Jason [3 ]
Rahim, Imran [3 ]
Suss, Amy [4 ]
Kohlhoff, Stephan [2 ]
Hammerschlag, Margaret R. [2 ]
Moallem, Hamid Jack [1 ]
机构
[1] SUNY Hlth Sci Ctr, Dept Pediat, Div Allergy & Immunol, Brooklyn, NY 11203 USA
[2] SUNY Hlth Sci Ctr, Dept Pediat, Div Pediat Infect Dis, Brooklyn, NY 11203 USA
[3] SUNY Hlth Sci Ctr, Dept Med, Div Cardiol, Brooklyn, NY 11203 USA
[4] SUNY Hlth Sci Ctr, Dept Pediat, Div Adolescent Med, Brooklyn, NY 11203 USA
关键词
Chlamydia pneumoniae; systemic lupus erythematosus; atherosclerosis; dyslipidemia; CIMT; vasculitis;
D O I
10.1007/s00246-007-9131-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Patients with systemic lupus erythematosus (SLE) have accelerated atherogenesis. A recent study suggested that Chlamydia pneumoniae infection might also be a contributing factor in the development of atherogenesis in patients with SLE. The objective of this study was to investigate the possible association of C. pneumoniae infection with markers of atherosclerosis in adolescents with SLE compared with age-matched healthy controls. History and exam focused on cardiovascular risk factors were obtained from 20 patients with SLE and 20 age- and sex-matched controls. Laboratory studies included serum lipid profile and high-sensitivity C-reactive protein (hsCRP). Detection of C. pneumoniae in peripheral blood mononuclear cells (PBMCs) and in nasopharyngeal swab specimens was performed. Carotid Intima-Media Thickness (CIMT) was determined by sonography in all subjects. C. pneumoniae DNA was not detected in PBMCs of any of the patients or controls. Nasopharyngeal cultures were also negative for C. pneumoniae in all patients. CIMT was slightly higher in the SLE group (0.48 +/- 0.049) compared with controls (0.454 +/- 0.041, p = 0.29). There was no significant difference between the two groups in body mass index, blood pressure, hsCRP, and serum cholesterol (total, LDL and HDL). Serum triglycerides were higher in the lupus group (p = 0.03). Children and adolescents with SLE might have accelerated atherosclerosis; however, we did not observe an association with C. pneumoniae infection in this population.
引用
收藏
页码:545 / 551
页数:7
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