Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens

被引：19

作者：

Blankenship, JR

Singh, N

Alexander, BD

Heitman, J

机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA

[4] Pittsburgh Vet Affairs Med Ctr, Div Infect Dis, Pittsburgh, PA USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 01期

关键词：

D O I：

10.1128/JCM.43.1.464-467.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.

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收藏

页码：464 / 467

页数：4

相关论文

共 37 条

[1] RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans [J].

Alspaugh, JA ;

Cavallo, LM ;

Perfect, JR ;

Heitman, J .

MOLECULAR MICROBIOLOGY, 2000, 36 (02) :352-365

[2]

BAHN YS, 2004, CELL, V3, P1476

[3]

Blankenship Jill R, 2003, Curr Opin Investig Drugs, V4, P192

[4] CALCINEURIN IS ESSENTIAL IN CYCLOSPORINE-A-SENSITIVE AND FK506-SENSITIVE YEAST STRAINS [J].

BREUDER, T ;

HEMENWAY, CS ;

MOVVA, NR ;

CARDENAS, ME ;

HEITMAN, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (12) :5372-5376

[5] TARGETS OF IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEXES ARE DISTINCT HIGHLY CONSERVED REGIONS OF CALCINEURIN-A [J].

CARDENAS, ME ;

MUIR, RS ;

BREUDER, T ;

HEITMAN, J .

EMBO JOURNAL, 1995, 14 (12) :2772-2783

[6] COMPLEMENTATION OF A CAPSULE-DEFICIENT MUTATION OF CRYPTOCOCCUS-NEOFORMANS RESTORES ITS VIRULENCE [J].

CHANG, YC ;

KWONCHUNG, KJ .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) :4912-4919

[7] INFECTIONS WITH CRYPTOCOCCUS-NEOFORMANS IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].

CHUCK, SL ;

SANDE, MA .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (12) :794-799

[8] IDENTIFICATION OF CALCINEURIN AS A KEY SIGNALING ENZYME IN LYMPHOCYTE-T ACTIVATION [J].

CLIPSTONE, NA ;

CRABTREE, GR .

NATURE, 1992, 357 (6380) :695-697

[9] Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans [J].

Cruz, MC ;

Sia, RAL ;

Olson, M ;

Cox, GM ;

Heitman, J .

INFECTION AND IMMUNITY, 2000, 68 (02) :982-985

[10] CAPSULE SIZE OF CRYPTOCOCCUS-NEOFORMANS - CONTROL AND RELATIONSHIP TO VIRULENCE [J].

DYKSTRA, MA ;

FRIEDMAN, L ;

MURPHY, JW .

INFECTION AND IMMUNITY, 1977, 16 (01) :129-135

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