Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH

被引：94

作者：

Miranda, KM ^{[1
]}

Dutton, AS

Ridnour, LA

Foreman, CA

Ford, E

Paolocci, N

Katori, T

Tocchetti, CG

Mancardi, D

Thomas, DD

Espey, MG

Houk, KN

Fukuto, JM

Wink, DA

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[3] NCI, Radiat Biol Branch, NIH, Bethesda, MD 20892 USA

[4] Univ Calif Los Angeles, Hlth Sci Ctr, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[5] Johns Hopkins Med Inst, Div Cardiol, Dept Med, Baltimore, MD 21287 USA

[6] Johns Hopkins Med Inst, Dept Biomed Engn, Baltimore, MD 21287 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 02期

关键词：

D O I：

10.1021/ja045480z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.

引用

页码：722 / 731

页数：10

共 81 条

[1] THE ULTRA-VIOLET ABSORPTION SPECTRA OF SODIUM HYPONITRITE AND SODIUM ALPHA-OXYHYPONITRITE - THE ANALYSIS OF MIXTURES WITH SODIUM NITRITE AND NITRATE [J].