Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans

被引：70

作者：

King, Katherine Y. ^{[1
]}

Lew, Justin D. ^{[2
]}

Ha, Ngan P. ^{[2
]}

Lin, Jeffery S. ^{[3
]}

Ma, Xin ^{[2
]}

Graviss, Edward A. ^{[2
]}

Goodell, Margaret A. ^{[4
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Infect Dis Sect, Houston, TX 77030 USA

[2] Methodist Hosp, Res Inst, Ctr Mol & Translat Human Infect Dis Res, Houston, TX 77030 USA

[3] Univ Calif Berkeley, Berkeley, CA 94720 USA

[4] Baylor Coll Med, Stem Cells & Regenerat Med Ctr, Houston, TX 77030 USA

来源：

PLOS ONE | 2011年 / 6卷 / 01期

关键词：

INTRACELLULAR PATHOGENS; CROHNS-DISEASE; IMMUNITY; GENE; RESISTANCE; GTPASES;

D O I：

10.1371/journal.pone.0016317

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.

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