A convenient access to αVβ3/αVβ5 integrin ligand conjugates:: regioselective solid-phase functionalisation of an RGD based peptide

被引：42

作者：

Boturyn, D ^{[1
]}

Dumy, P ^{[1
]}

机构：

[1] Univ Grenoble 1, CNRS, UMR 5616, LEDSS, F-38041 Grenoble 9, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 15期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)00293-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclopeptide (-RGDfK-) is a potent and selective alpha (V)beta (3)/alpha (V)beta (5) integrin ligand. A methodology for the conjugation of cyclo(-RGDfK-) through the regioselective derivatisation of lysine side chains, either in solution or directly on the solid support, is described. This provides a rapid and flexible chemical entry to conjugated integrin ligands bearing reporter groups for biological investigations or reactive chemical functions for the preparation of new vector systems. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2787 / 2790

页数：4

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