Tissue distribution of the human CD97 EGF-TM7 receptor

被引:71
作者
Jaspars, LH
Vos, W
Aust, G
van Lier, RAW
Hamann, J
机构
[1] Free Univ Amsterdam, Acad Hosp, Dept Pathol, Amsterdam, Netherlands
[2] Univ Leipzig, Fac Med, Inst Pathol, Leipzig, Germany
[3] Univ Amsterdam, Acad Med Ctr, Dept Immunol, CLB, NL-1105 AZ Amsterdam, Netherlands
[4] Univ Amsterdam, Acad Med Ctr, Expt & Clin Immunol Lab, NL-1105 AZ Amsterdam, Netherlands
来源
TISSUE ANTIGENS | 2001年 / 57卷 / 04期
关键词
CD97; class II seven-span transmembrane receptors; EGF-TM7; family; histology;
D O I
10.1034/j.1399-0039.2001.057004325.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
CD97 is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) receptors. CD97 has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to CD55. Previous studies demonstrated the expression of CD97 on activated lymphocytes, monocytes, macrophages, granulocytes, and numerous haematopoietic and nonhaematopoietic cell lines. Here, we determined the cellular distribution of human CD97 in situ by immunohistochemistry M and immunofluorescence (IF). Abundant expression of CD97 was detected on all types of macrophages and dendritic cells, except for microglia, Within the lymphoid lineage, most T cells but only a few B cells express CD97. Germinal centre B cells do not express the molecule. Except for smooth muscle cells, no staining was found on other cells outside the immune system. However, analysis of a restricted set of epithelial tumors revealed CD97 expression on the malignant cells in thyroid and gastrointestinal tract cancer.
引用
收藏
页码:325 / 331
页数:7
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