A practical synthesis of (R)-3-chlorostyrene oxide starting from 3-chloroethylbenzene

被引：24

作者：

Tanaka, K ^{[1
]}

Yasuda, M ^{[1
]}

机构：

[1] Mitsubishi Chem Corp, Yokohama Res Ctr, Aoba Ku, Kanagawa 2278502, Japan

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 18期

关键词：

D O I：

10.1016/S0957-4166(98)00337-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel and practical synthesis of (R)-3-chlorostyrene oxide (-)-1 was achieved starting from commercially available 3-chloroethylbenzene 3. Enantiopure (-)-3-chlorostyrene bromohydrin (-)-5 was obtained by the treatment of racemic (+/-)-5 with lipase QL in the presence of acylating reagents. 3-Chloro-alpha,beta-dibromoethylbenzene 4, a precursor of (+/-)-5, was synthesized via the expeditious bromination of 3 which was developed by these authors. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3275 / 3282

页数：8

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