Inflammatory Genes in Epicardial Fat Contiguous With Coronary Atherosclerosis in the Metabolic Syndrome and Type 2 Diabetes Changes associated with pioglitazone

被引：102

作者：

Sacks, Harold S. ^{[1
,2
]}

Fain, John N. ^{[3
]}

Cheema, Paramjeet ^{[3
]}

Bahouth, Suleiman W. ^{[4
]}

Garrett, Edward ^{[2
]}

Wolf, Rodney Y. ^{[2
]}

Wolford, David ^{[2
]}

Samaha, Joseph ^{[2
]}

机构：

[1] Univ Tennessee, Ctr Hlth Sci, Coll Med, Dept Med, Memphis, TN 38163 USA

[2] Baptist Mem Hosp, Baptist Heart Inst, Memphis, TN 38146 USA

[3] Univ Tennessee, Ctr Hlth Sci, Coll Med, Dept Mol Sci, Memphis, TN 38163 USA

[4] Univ Tennessee, Ctr Hlth Sci, Coll Med, Dept Pharmacol, Memphis, TN 38163 USA

来源：

DIABETES CARE | 2011年 / 34卷 / 03期

关键词：

INTERLEUKIN-1 RECEPTOR ANTAGONIST; ADIPOSE-TISSUE;

D O I：

10.2337/dc10-2083

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-To determine changes in gene expression in epicardial adipose tissue (EAT) associated with coronary atherosclerosis (CAD) and effects of pioglitazone therapy. RESEARCH DESIGN AND METHODS-Genes were quantified by RT-PCR in EAT and thoracic subcutaneous adipose tissue (SAT) obtained during surgery in CAD patients with metabolic syndrome (MS) or type 2 diabetes and control subjects with minimal or no CAD and no MS or type 2 diabetes. RESULTS-Increased expression of interleukin-1 receptor antagonist (IL-1Ra) and IL-10, a trend for higher IL-1 beta, and no change in peroxisome proliferator activated receptor-gamma (PPAR gamma) was found in EAT from MS or type 2 diabetes. Only PPAR gamma mRNA was reduced in SAT. Pioglitazone therapy in type 2 diabetes was associated with decreased expression of IL-1 beta, IL-1Ra, and IL-10 in EAT; decreased IL-10 in SAT; and increased PPAR gamma in SAT. CONCLUSIONS-In MS and type 2 diabetes with CAD, proinflammatory and anti-inflammatory genes were differentially increased in EAT and selectively reduced in association with pioglitazone treatment.

引用

页码：730 / 733

页数：4

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