Annexins and endocytosis

被引：120

作者：

Futter, Clare E. ^{[1
]}

White, Ian J. ^{[1
]}

机构：

[1] UCL, Inst Ophthalmol, London EC1V 9EL, England

来源：

TRAFFIC | 2007年 / 8卷 / 08期

基金：

英国惠康基金;

关键词：

annexin; clathrin; lysosome; multivesicular body;

D O I：

10.1111/j.1600-0854.2007.00590.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Annexins are calcium- and phospholipid-binding proteins that have been proposed to have multiple roles in membrane traffic. Historically, this has been based on the in vitro properties of annexins and their localization to specific membrane compartments. However, recent functional evidence supports a role for annexins in specific membrane traffic steps, although the requirement for annexins may be highly dependent on the cellular context. Here we review the roles of annexins in traffic within the endocytic pathway, focusing on clathrin-dependent internalization from the plasma membrane, multivesicular endosome/body (MVB) biogenesis and MVB-lysosome fusion.

引用

收藏

页码：951 / 958

页数：8

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