Putting proteins back into water

被引:59
作者
De Los Rios, P [1 ]
Caldarelli, G
机构
[1] Univ Fribourg, Inst Phys Theor, CH-1700 Fribourg, Switzerland
[2] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy
[3] INFM, Sez Roma 1, I-00185 Rome, Italy
关键词
D O I
10.1103/PhysRevE.62.8449
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
We introduce a simplified protein model where the solvent (water) degrees of freedom appear explicitly (although in an extremely simplified fashion). Using this model we are able to recover the thermodynamic phenomenology of proteins over a wide range of temperatures. In particular we describe both the warm and the cold protein denaturation within a single framework, while addressing important issues about the structure of model proteins.
引用
收藏
页码:8449 / 8452
页数:4
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