Microbe Hunting

被引:85
作者
Lipkin, W. Ian [1 ]
机构
[1] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY 10032 USA
基金
美国国家卫生研究院;
关键词
BORNA-DISEASE VIRUS; MEDIATED ISOTHERMAL AMPLIFICATION; LYMPHOCYTE CYTOKINE PROFILES; RESPIRATORY-SYNCYTIAL-VIRUS; POLYMERASE-CHAIN-REACTION; RETRACTED ARTICLE. SEE; NEW-YORK-CITY; HUMAN-RHINOVIRUS; HUMAN-PAPILLOMAVIRUS; INFLUENZA-VIRUS;
D O I
10.1128/MMBR.00007-10
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Platforms for pathogen discovery have improved since the days of Koch and Pasteur; nonetheless, the challenges of proving causation are at least as daunting as they were in the late 1800s. Although we will almost certainly continue to accumulate low-hanging fruit, where simple relationships will be found between the presence of a cultivatable agent and a disease, these successes will be increasingly infrequent. The future of the field rests instead in our ability to follow footprints of infectious agents that cannot be characterized using classical microbiological techniques and to develop the laboratory and computational infrastructure required to dissect complex host-microbe interactions. I have tried to refine the criteria used by Koch and successors to prove linkage to disease. These refinements are working constructs that will continue to evolve in light of new technologies, new models, and new insights. What will endure is the excitement of the chase. Happy hunting! Copyright © 2010, American Society for Microbiology. All Rights Reserved.
引用
收藏
页码:363 / +
页数:16
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