Systemic lupus erythematosus:: new molecular targets

被引:27
作者
Crispin, Jose C. [1 ]
Kyttaris, Vasileios C. [1 ]
Juang, Yuang-Taung [1 ]
Tsokos, George C. [1 ]
机构
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA
关键词
D O I
10.1136/ard.2007.078493
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
T cells from patients with systemic lupus erythematosus exhibit a notable array of defects that probably contribute to the origin and development of the disease. Such abnormalities include an abnormal response to stimulation, aberrant expression of molecules that play key roles in intracellular signalling pathways, altered transcription factor activation and binding, and skewed gene expression. The combination of these alterations leads the cell to the expression of a particular phenotype that intense research has gradually uncovered over the last years. The aim of this article is to review the findings that have allowed us to better understand the behaviour of the lupus T cell and highlight the molecules that represent potential therapeutic targets.
引用
收藏
页码:65 / 69
页数:5
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