Productive infection of T cells in lymphoid tissues during primary and early human immunodeficiency virus infection

被引:96
作者
Schacker, T
Little, S
Connick, E
Gebhard, K
Zhang, ZQ
Krieger, J
Pryor, J
Havlir, D
Wong, JK
Schooley, RT
Richman, D
Corey, L
Haase, AT
机构
[1] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Dept Urol Surg, Minneapolis, MN 55455 USA
[4] Univ Washington, Dept Urol, Seattle, WA 98195 USA
[5] Univ Washington, Dept Med, Seattle, WA 98195 USA
[6] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA
[7] Fred Hutchinson Canc Res Ctr, Program Infect Dis, Seattle, WA 98104 USA
[8] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA
[9] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA
[10] Univ Colorado, Hlth Sci Ctr, Denver, CO USA
[11] San Diego Vet Affairs Med Ctr, Denver, CO USA
关键词
D O I
10.1086/318524
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Current models suggest that during human immunodeficiency virus type 1 (HIV-1) transmission virions are selected that use the CCR5 chemokine receptor on macrophages and/or dendritic cells. A gradual evolution to CXCR4 chemokine receptor use causes a shift in the proportion of productively infected cells to the CD4 cell population. Productively infected cells during acute and early infection in lymphoid tissue were assessed, as well as the impact of productive infection on the T cell population in 21 persons who had biopsies performed on days 2-280 after symptoms of acute HIV-1 seroconversion. Even in the earliest stages of infection, most productively infected cells were T lymphocytes. There were sufficient infected cells in lymphoid tissue (LT) to account for virus production and virus load in plasma. Despite the relatively high frequency of productively infected cells in LT, the impact on the size of the T cell population in LT at this stage was minor.
引用
收藏
页码:555 / 562
页数:8
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