Nephrogenic diabetes insipidus induced by lobenzarit disodium treatment in patients with rheumatoid arthritis

Nephrogenic diabetes insipidus (NDI) occurred in a 43-year-old woman who had received lobenzarit disodium for the treatment of rheumatoid arthritis (RA). Her urine output was initially 3 l/day and urine osmolarity was 203 mOsm/l. Based on a sodium chloride loading test and a vasopressin loading test, she was diagnosed as having lobenzarit-induced NDI, Seven days after the cessation of the use of lobenzarit disodium, polydipsia and polyuria disappeared, and the vasopressin test showed a normal response, These findings suggest that lobenzarit induces a reversible form of NDI as a side effect, The reports of lobenzarit-induced NDI in Japan during the past seven years are also reviewed.